CD19 anticorps

N° du produit ABIN616757

L’anticorps Rat Monoclonal anti-CD19 a été validé pour FACS, IP, IHC (fro) et Func. Il convient pour détecter CD19 dans des échantillons de Souris.

Aperçu rapide pour CD19 anticorps (ABIN616757)

Antigène: CD19 (CD19 Molecule (CD19))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD19 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Clone: 1D3

Détail du produit anti-CD19 anticorps

Specificité: This antibody detects detects mouse CD19, 95 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells, it is lost on plasma cells.

Réactivité croisée (Details): Species reactivity (tested):Mouse

Purification: Protein-G affinity chromatography

niveau d'endotoxine: Less than 10 EU/mg of the protein, as determined by the LAL test

Immunogène: Mouse CD19-transfected cell line

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Azide free PBS, pH ~7.4

Agent conservateur: Azide free

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CD19

Antigène: CD19 (CD19 Molecule (CD19))

Autre désignation: CD19

Sujet: CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.Synonyms: B-cell marker, B-lymphocyte surface antigen B4, Differentiation antigen CD19, Leu-12

ID gène: 12478

NCBI Accession: NP_033974

UniProt: P25918

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway